The presence of the virus had been confirmed in a 34-year-old pregnant woman who was admitted to hospital last month after showing symptoms that included a high fever and repeated vomiting, the ministry added.
She died a few hours later from multiple organ failure.
This will be the 16th outbreak of the de.adly virus in the vast central African state that has poor health services, and is hit by conflict in the east.
The latest outbreak is in central Kasai province, with 28 suspected cases recorded, the ministry said.
Officials have urged strict adherence to preventive measures, including frequent handwashing and social distancing in high-risk areas.
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